Calpain Inhibitor III-CAS 88191-84-8-Calbiochem

C₂₂H₂₆N₂O₄

382.45

MFCD00798796

NA.77

A potent, cell-permeable inhibitor of calpain I and II (K_i = 8 nM) that also reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effects against glutamate-induced toxicity.
A potent, cell-permeable inhibitor of calpain I and II (K_i = 8 nM). Reduces capsaicin-mediated cell death in cultured dorsal root ganglion. Reported to block A23187-induced suppression of neurite outgrowth in isolated hippocampal pyramidal neurons. Exhibits neuroprotective effect in glutamate-induced toxicity.

Cell permeable: yes
Primary Target
calpain 1, calpain 2
Product does not compete with ATP.
Reversible: no

Toxicity: Standard Handling (A)

Z-Val-Phe-CHO

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Chatterjee, S., et al. 1998. J. Med. Chem.41, 2663.
Rami, A., et al. 1997. Neurosci. Res. 27, 93.
Yamazaki, T., et al. 1997. Biochemistry36, 8377.
Klafki, H., et al. 1996. J. Biol. Chem.271, 28655.
Chard, P.S., et al. 1995. Neuroscience 65, 1099.
Song, D.K., et al. 1994. J. Neurosci. Res. 39, 474.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

lyophilized solid

8 nM IC₅₀

Calbiochem^®

OK to freeze

white

DMSO: 20 mg/mL (Use only anhydrous DMSO.)

ambient

2-8℃

1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19-,20-/m0/s1

NGBKFLTYGSREKK-PMACEKPBSA-N

25 mg in Plastic ampoule

11 - Combustible Solids

WGK 3