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TCPOBOP-CAS 76150-91-9-Calbiochem
| 产品编号： | 4152484 |
| 规格： | The most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents. |
| CAS NO： | 76150-91-9 |
| 包装规格： | 25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4152484 | 25 MG | 2790 |
产品别名
76150-91-9
TCPOBOP-CAS 76150-91-9-Calbiochem
1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H8Cl4N2O2 |
| Molecular weight | 402.06 |
| MDL number | MFCD00057368 |
| General description【一般描述】 | A highly potent inducer of phenobarbital-like class of cytochrome P450 (CYP) enzymes. A tumor promoter that induces hepatocyte proliferation, independent of the presence of cytokines or transcription factors. Activates orphan nuclear receptors mCAR (mouse constitutive androstane receptor) and hPXR (human pregane X receptor), but has little or no effect on hCAR and mPXR. Also suppresses the expression of multi-drug resistance genes mdr2 and mdr3 in mouse liver. The most potent known member of the phenobarbital-like class of cytochrome P450 (CYP)-inducing agents. Acts as a tumor promoter of murine hepatocarcinogenesis; activates orphan nuclear receptors mCAR (mouse Constitutive Androstane Receptor) and hPXR (human Pregnane X Receptor), but has little or no activity on hCAR and mPXR. Also suppresses the multidrug resistance gene expression in the mouse liver. |
| Biochem/physiol Actions【生化/生理作用】 | Primary Target Cytochrome P450 (CYP)-inducing agents Product does not compete with ATP. Reversible: no Cell permeable: no |
| Warning【警告】 | Toxicity: Carcinogenic / Teratogenic (D) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Ledda-Columbano, G.M., et al. 2000. Am. J. Pathol.156, 91. Moore, L.B., et al. 2000. J. Biol. Chem.275, 15122. Tzameli, I., et al. 2000. Mol. Cell. Biol.20, 2951. Forman, B.M., et al. 1998. Nature395, 612. Honkakoski, P., et al. 1998. Mol. Pharmacol.53, 597. Russell, A.L., et al. 1994. Int. J. Cancer58, 550. Smith, G., et al. 1993. Biochem. J.289, 807. Dargani, T.A., et al. 1990. Carcinogenesis11, 1153. Poland, A., et al. 1980. Mol. Pharmacol.18, 571. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 5 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C16H8Cl4N2O2/c17-9-5-13(19)15(21-7-9)23-11-1-2-12(4-3-11)24-16-14(20)6-10(18)8-22-16/h1-8H |
| InChI key | BAFKRPOFIYPKBQ-UHFFFAOYSA-N |
| packaging【包装】 | 25 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
