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(S,R,S)-AHPC-PEG2-butyl chloride
产品别名
1835705-57-1
(S,R,S)-AHPC-PEG2-butyl chloride
Protein degrader building block for PROTAC research
(2S,4R)-1-((S)-2-(2-(2-((6-Chlorohexyl)oxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
VH032 conjugate
Template for synthesis of targeted protein degrader
Crosslinker-E3 Ligase ligand conjugate
(S,R,S)-AHPC-2-2-6-Cl
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C32H47ClN4O6S |
| Molecular weight | 651.26 |
| MDL number | MFCD31560480 |
| Application【应用】 | Protein degrader builiding block (S,R,S)-AHPC-PEG2-Butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. |
| Other Notes【其他说明】 | Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC® Degraders for Targeted Protein Degradation Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL Targeted Protein Degradation by Small Molecules Small-Molecule PROTACS: New Approaches to Protein Degradation Targeted Protein Degradation: from Chemical Biology to Drug Discovery Impact of linker length on the activity of PROTACs |
| Legal Information【法律信息】 | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
产品性质
| Assay【测定】 | ≥95% |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | ClCCCCCCOCCOCC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O ClCCCCCCOCCOCC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
