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(S,R,S)-VL285 Phenol-C3-piperazine hydrochloride
产品别名
(S,R,S)-VL285 Phenol-C3-piperazine hydrochloride
Crosslinker-E3 Ligase ligand conjugate
(2S,4R)-4-Hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)-N-(4-(4-methylthiazol-5-yl)-2-((6-(3-(piperazin-1-yl)propoxy)pyridin-3-yl)methoxy)benzyl)pyrrolidine-2-carboxamide
VHL protein degrader building block for PROTAC research
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C42H51N7O6S · xHCl |
| Molecular weight | 781.96 (free base basis) |
| Application【应用】 | Protein degrader building block (S,R,S)-VL285 Phenol-C3-piperazine hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand with alternative exit vector from the widely used VH032 (901490), a linker with added rigidity, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a terminal amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. |
| Other Notes【其他说明】 | Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC® Degraders for Targeted Protein Degradation Targeted Protein Degradation by Small Molecules Targeted Protein Degradation: from Chemical Biology to Drug Discovery HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase |
| Legal Information【法律信息】 | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
产品性质
| Quality Level【质量水平】 | 100 |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C([C@@H]1C[C@@H](O)CN1C([C@H](C(C)C)N2CC(C=CC=C3)=C3C2=O)=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4OCC6=CC=C(OCCCN7CCNCC7)C=N6.Cl O=C([C@@H]1C[C@@H](O)CN1C([C@H](C(C)C)N2CC(C=CC=C3)=C3C2=O)=O)NCC4=CC=C(C5=C(C)N=CS5)C=C4OCC6=CC=C(OCCCN7CCNCC7)C=N6.Cl |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
