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3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine
产品别名
952143-02-1
3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine
Suzuki-Miyaura-compatible multifunctional photo probe building block
Trifluoromethyl diazirine aryl bromide
Probe building block for photoaffinity labeling
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C8H4BrF3N2 |
| Molecular weight | 265.03 |
| Application【应用】 | 3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine is a Suzuki-Miyaura (S−M)-compatible building block tailored for the design of photoaffinity probes (PAPs). Photoaffinity labeling (PAL) is of growing interest in chemical biology and drug discovery research for use in protein profiling; covalent inhibitors; protein-protein interactions and complexes; and target engagement, identification, or validation studies. Diazirines are desirable photoactivable groups for chemical probes; however, their installation is not always straightforward. In response, diazirine-tolerant S-M coupling conditions were developed by Ichiishi, et al, using 3-(4-bromophenyl)-3-(trifluoromethyl)-3H-diazirine and shown to be efficient and scalable with minimal perturbation of the diazirine. |
| Other Notes【其他说明】 | Reducing Limitation in Probe Design: The Development of a Diazirine-Compatible Suzuki-Miyaura Cross Coupling Reaction |
产品性质
| Assay【测定】 | ≥95% |
| form【形式】 | liquid |
| reaction suitability | reagent type: cross-linking reagent |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | BrC1=CC=C(C2(N=N2)C(F)(F)F)C=C1 |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
