3-Nitropropionic acid-CAS 504-88-1-Calbiochem

C₃H₅NO₄

119.08

MFCD00007406

A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.

Toxicity: Toxic (F)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Beal, M., et al. 1993, J. Neurosci.13, 4181.
Pang, Z., et al. 1997, J. Neuroscience17, 3064.
Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.
Garcia, M., et al. 2002, J. Neurosci. 22, 2174.
Kim, G. W., et al. 2003, J. Neurosci.23, 8733.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (NMR)

powder

Calbiochem^®

OK to freeze
protect from light

light yellow

ethanol: 100 mg/mL
DMSO: soluble

ambient

2-8℃

1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)

WBLZUCOIBUDNBV-UHFFFAOYSA-N

50 mg in Glass bottle
Packaged under inert gas

GHS06

Danger

H301

P264 - P270 - P301 + P310 - P405 - P501

Acute Tox. 3 Oral

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK 3