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4-(2-(Hex-5-ynamido)ethyl)benzenesulfonyl fluoride
产品别名
1375960-13-6
4-(2-(Hex-5-ynamido)ethyl)benzenesulfonyl fluoride
SFABP
Sulfonyl fluoride activity-based probe
DAS1
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H16FNO3S |
| Molecular weight | 297.35 |
| Application【应用】 | 4-(2-(Hex-5-ynamido)ethyl)benzenesulfonyl fluoride is an alkyne-functionalized sulfonyl fluoride activity-based probe (SFABP). Sulfonyl fluorides covalently modify reactive serines in addition to threonine, lysine, tyrosine, cysteine, and histidine residues in a context-specific manner. Activity-based probes are useful for the targeting, isolation, and identification of proteins. Furtermore, the alkyne handle on SFABP enables click chemistry-based incorpoation of azide tags, such as fluorophores or biotins, for visualization or enrichment and detection, respectively. |
| Other Notes【其他说明】 | Unbiased Mass Spectrometry Elucidation of the Targets and Mechanisms of Activity-Based Probes: A Case Study Involving Sulfonyl Fluorides Sulfonyl fluorides as privileged warheads in chemical biology Chemical Proteomics with Sulfonyl Fluoride Probes Reveals Selective Labeling of Functional Tyrosines in Glutathione Transferase Sulfonyl Fluoride Analogues as Activity-Based Probes for Serine Proteases Europium-Labeled Activity-Based Probe through Click Chemistry: Absolute Serine Protease Quantification Using 153Eu Isotope Dilution ICP/MS |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% |
| form【形式】 | powder |
| storage temp.【储存温度】 | −20℃ |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 |
| Precautionary Statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
