Adenosine Deaminase Inhibitor, DCF-CAS 53910-25-1-Calbiochem

C₁₁H₁₆N₄O₄

268.27

A cell-permeable purine nucleoside compound that acts as a highly potent, tight binding transition state analog inhibitor of adenosine deaminase (ADA; K_i= 2.5 pM against partially purified human erythrocytes, and 0.48 to 9.1 nM against rat liver, rat intestine, rat hepatoma and human B cells). Reported to be an immunomodulator and exert selective toxicity towards lymphocytes.

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Robak, T. 2007. Cancer Treat. Rev.33, 710.
Klohs, W.D. and Kraker, A.J., 1992. Pharmacol. Rev.44, 459.
Agarwal, R.P., et al. 1977. Biochem. Pharmacol.26, 359.
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CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

white

DMSO: 10 mg/mL, clear, colorless
water: 50 mg/mL, clear, colorless

ambient

2-8℃

O[C@@H]1CNC=NC2=C1N=CN2[C@@H]3O[C@H](CO)[C@H](O)C3[H]

1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1

FPVKHBSQESCIEP-JQCXWYLXSA-N

10 mg in Glass bottle
Packaged under inert gas

GHS06

Danger

H301

P264 - P270 - P301 + P310 - P405 - P501

Acute Tox. 3 Oral

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK 3