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Anti-Cytoplasmic FMR1-interacting protein 1 Antibody
| 产品编号： | 4154299 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-Cytoplasmic FMR1-interacting protein 1 Antibody
cytoplasmic FMR1 interacting protein 1, Specifically Rac1-associated protein 1, cytoplasmic FMRP interacting protein 1, cytoplasmic FMR1-interacting protein 1, selective hybridizing clone
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Cytoplasmic FMR1-interacting protein 1 (CYFIP1) is a member of the CYFIP family. It is a component of the CYFIP1-EIF4E-FMR1 complex, a regulatory complex for translational repression that binds to the mRNA cap. Within the complex, CYFIP1 serves as an adapter between the other two components and upregulates the translation repression activity of FMR1. It regulates epithelial morphogenesis, binds F-actin, and is a component in the development and formation of axon outgrowth, lamellipodia, protrusions, and membrane ruffles. Through its interaction with RAC1, CYFIP1 regulates the activity of WASP family members. CYFIP1 is associated with Prader-Willi/Angelman syndromes and may also have a role in autism. |
| Immunogen【免疫原】 | KLH-conjugated linear peptide corresponding to an internal sequence (a.a.519-532) of human Cytoplasmic FMR1-interacting protein 1. Epitope: Unknown |
| Application【应用】 | Research Sub Category Cytoskeletal Signaling Research Category Cell Structure Signaling Detect Cytoplasmic FMR1-interacting protein 1 using this Anti-Cytoplasmic FMR1-interacting protein 1 Antibody validated for use in WB & IC. Western Blot (Snap i.d. Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected Cytoplasmic FMR1-interacting protein 1 in NIH/3T3, HeLa, and A431 cells. |
| Quality【质量】 | Evaluated by Western Blot in HeLa cell lysate. Western Blot Analysis: 1 µg/mL of the antibody detected Cytoplasmic FMR1-interacting protein 1 on 10 µg of HeLa cell lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control HeLa cell lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human, mouse |
| species reactivity (predicted by homology) | primate (based on 100% sequence homology), rat (based on 100% sequence homology), rhesus macaque (based on 100% sequence homology), bovine (based on 100% sequence homology) |
| technique(s) | immunocytochemistry: suitable western blot: suitable |
| UniProt accession no.【UniProt登记号】 | Q7L576 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... SRA1(10011) |
产品说明
| Target description【目标描述】 | ~ 154 kDa observed. There are three noted isoforms with calculated MWs of 51 kDa, 94 kDa, and 145 kDa Additional isoforms may be observed in some lysates. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
