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Anti-LCN2 Antibody
| 产品编号： | 4154557 |
| 规格： | from rabbit, purified by affinity chromatography |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-LCN2 Antibody
lipocalin 2, migration-stimulating factor inhibitor, siderocalin, Oncogene 24p3, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, lipocalin 2 (oncogene 24p3), neutrophil gelatinase-associated lipocalin, Lipocalin-2
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | LCN2 (also known as Neurophil Gelatinase-Associated Lipocalin or NGAL) belongs to a superfamily of lipocalins, a collection of small, diversely functional, extracellular proteins. NGAL is secreted from neutrophil granules in three different forms; a monomer of 25 kDa, a disulfide-linked homodimer at 46 kDa, and a disulfide-linked heterodimer with MMP-9 at 135-kDa. It is widely known to induce development of kidney epithelia, to bind and traffic iron, and to act as a molecular signal under inflammatory conditions, such as Crohn’s Disease. Multiple carcinoma studies have also shown elevated expression levels of LCN2 in several different human tumors affecting such organs as: colon, lung, breast, ovaries and pancreas. Additionally, there has been great interest in this protein as a possible marker for: onset of Acute Kidney Injury following cardiac surgery, the progression of Chronic Kidney Disease (CKD), and the survival chances of patients with Chronic Heart Failure (CHF). |
| Specificity【特异性】 | This antibody recognizes LCN2. |
| Immunogen【免疫原】 | Epitope: Mature chain KLH-conjugated linear peptide corresponding to the mature chain of human LCN2. |
| Application【应用】 | Immunohistochemistry Analysis: A 1:200 dilution of Anti-LCN2 antibody from a previous lot detected LCN2 in human spleen tissue. Research Category Neuroscience Research Sub Category Neurodegenerative Diseases Anti-LCN2 Antibody detects level of LCN2 & has been published & validated for use in WB, IH. |
| Quality【质量】 | Evaluated by Western Blot in human kidney tissue lysate. Western Blot Analysis: 5 µg/mL of this antibody detected LCN2 in 10 µg of human kidney tissue lysate. |
| Physical form【外形】 | Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. Affinity purified |
| Analysis Note【分析说明】 | Control Human kidney tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | human |
| species reactivity (predicted by homology) | bovine (based on 100% sequence homology), mouse (based on 100% sequence homology), rat (based on 100% sequence homology) |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NP_005555 |
| UniProt accession no.【UniProt登记号】 | P80188 |
| shipped in【运输】 | wet ice |
产品说明
| Target description【目标描述】 | LCN2 band observed at 25 kDa Heavy concentration of tissue lysate and a 5 minute exposure time were used to generate the band of interest. |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at 2-8°C from date of receipt. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
