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Anti-Pleiotrophin Antibody, clone 3B10
产品别名
Anti-Pleiotrophin Antibody, clone 3B10
pleiotrophin, neurite growth-promoting factor 1, Heparin-binding brain mitogen, heparin binding growth factor 8, Heparin-binding growth-associated molecule, heparin affin regulatory protein, Heparin-binding neurite outgrowth-promoting factor 1, pleiotrop
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | Pleiotrophin (PTN) also called Neurite Growth-promoting Factor 1 (NEGF1) or HARP (Heparin affin regulatory peptide) is a new member of the heparin-binding neurotrophic factor family. PTN plays an important role in development processess and promotion of neurite extension. During embryonic development, pleiotrophin is expressed in the central and peripheral nervous system, lung, kidney, gut and bone. Pleiotrophin is also expressed by several tumor cells and is thought to be involved in tumor angiogenesis. PTN initiates an angiogenic switch in different cancer models and acts as an angiogenic factor. PTN does this through an interaction with endothelial cells to initiate proliferation, migration, and tube formation. |
| Immunogen【免疫原】 | Recombinant protein corresponding to chicken Pleiotrophin. |
| Application【应用】 | Research Sub Category Apoptosis - Additional Developmental Neuroscience Research Category Apoptosis & Cancer Immunohistochemistry Analysis: A 1:500 dilution from a previous lot detected Pleiotrophin in papillary squamous cell carcinoma tissue. This Anti-Pleiotrophin Antibody, clone 3B10 is validated for use in IH, WB for the detection of Pleiotrophin. |
| Quality【质量】 | Evaluated by Western Blot in human placenta tissue lysate. Western Blot Analysis: 0.5 µg/mL of this antibody detected Pleiotrophin in 10 µg of human placenta tissue lysate. |
| Linkage【联系】 | Replaces: MABD179 |
| Physical form【外形】 | Format: Purified Purified mouse monoclonal IgG1κ in buffer containing PBS without 0.05% sodium azide. Protein G Purified |
| Analysis Note【分析说明】 | Control Human placenta tissue lysate |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| antibody form【抗体形式】 | purified antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | 3B10, monoclonal |
| species reactivity | human |
| technique(s) | immunohistochemistry: suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG1κ |
| NCBI accession no.【NCBI登记号】 | XP_416358 |
| UniProt accession no.【UniProt登记号】 | P32760 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... PTN(5764) |
产品说明
| Target description【目标描述】 | ~20 kDa observed |
| Storage and Stability【储存及稳定性】 | Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
