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Anti-Potassium Channel ERG1 Antibody, CT
产品别名
Anti-Potassium Channel ERG1 Antibody, CT
Ether-a-go-go-related Gene Product, HERG1, MERG1, RERG1
基本信息
| eCl@ss | 32160702 |
| NACRES | NA.41 |
| General description【一般描述】 | ERG1 encodes the pore forming alpha subunit of the voltage-gated channels that conduct the rapid delayed rectifier potassium current, which leads to termination of the cardiac ventricular action potential. A large number of commercially available therapeutic agents (antiarrhythmics, antihistamines, antibiotics and antidepressants) have been shown to preferentially block ERG1 and cause a disorder of cardiac action potential depolarization that predisposes affected individuals to ventricular arrhythmia and sudden death. |
| Specificity【特异性】 | ERG1 protein. By western blot, antibody recognizes bands at 175 and 205 kDa (glycosylated) or 135 and 165 kDa (deglycosylated). |
| Immunogen【免疫原】 | Synthetic peptide corresponding to the C-terminus of ERG1 (aa 1145-1159 of HERG1). Epitope: C-terminus |
| Application【应用】 | Anti-Potassium Channel ERG1 Antibody, C-terminus detects level of Potassium Channel ERG1 & has been published & validated for use in IC, IH, IP & WB. Immunoblotting: 5 μg/mL Immunocytochemistry Immunohistochemistry on 4% paraformaldehyde fixed tissues. Immunoprecipitation Optimal working dilutions must be determined by end user. Research Category Neuroscience Research Sub Category Ion Channels & Transporters |
| Physical form【外形】 | Liquid in PBS with 0.1% sodium azide. |
| Analysis Note【分析说明】 | Control Positive control tissue: Heart |
| Other Notes【其他说明】 | Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Legal Information【法律信息】 | CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| biological source【生物来源】 | rabbit |
| Quality Level【质量水平】 | 100 |
| antibody form【抗体形式】 | affinity purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| purified by【纯化方式】 | affinity chromatography |
| species reactivity | rat, human, mouse |
| manufacturer/tradename | Chemicon® |
| technique(s) | immunocytochemistry: suitable immunohistochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
| NCBI accession no.【NCBI登记号】 | NM_000238.2 NM_172056.1 NM_172057.1 |
| UniProt accession no.【UniProt登记号】 | Q12809 |
| shipped in【运输】 | wet ice |
| Gene Information | human ... KCNH2(3757) |
产品说明
| Storage and Stability【储存及稳定性】 | Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles |
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 2 |
