Anti-Substance P Antibody, pain

32160702

NA.41

Substance P is a tachykinin family neuropeptide that functions as a neurotransmitter and neuromodulator. In the CNS, Substance P is involved in the regulation of mood, anxiety, sleep, saiety, reinforcement, respiratory rhythm and pain processing. In nociception, the neuropeptide is released at local spinal cord synapse. Recent research now shows substance P is potentially involved in endothelial cell differentiation as well as diverse roles in neuroinflammatory response. The endogenous receptor for Substance P is neurokinin 1 receptor (NK1 receptor), which belongs to the tachykinin receptor sub-family of GPCRs.

Substance P

RIA:
1:10,000 dilution from a previous lot was used in radioimmunioassay. 80% binding detects at least 5 pg/mL.

Optimal working dilutions must be determined by the end user.
Research Sub Category
Neuroinflammation & Pain
This Anti-Substance P Antibody, pain is validated for use in IH(P), RIA for the detection of Substance P.
Research Category
Neuroscience

Immunohistochemistry(paraffin):
Substance P (AB1566) representative staining pattern/morphology in Alzheimer’s brain. Tissue pretreated with Citrate pH6.0, antigen retrieval. Antibody diluted to 1:100.
IHC-Paraffin Staining With Citrate pH 6.0 Epitope Retrieval: Alzheimer’s Brain.

Unpurified
Rabbit polyclonal serum containing 0.1% sodium azide.

Control
Spinal Cord.

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

rabbit

100

serum

primary antibodies

polyclonal

rat, mouse, human

Chemicon^®

immunohistochemistry: suitable (paraffin)
radioimmunoassay: suitable

NM_003182.1

P20366

dry ice

human ... TAC1(6863)

Stable for 1 year at -20ºC from date of receipt.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

10 - Combustible liquids

WGK 1