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Casein Kinase II Inhibitor I-CAS 17374-26-4-Calbiochem
| 产品编号： | 4155541 |
| 规格： | The Casein Kinase II Inhibitor I, also referenced under CAS 17374-26-4, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. |
| CAS NO： | 17374-26-4 |
| 包装规格： | 10 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4155541 | 10 MG | 1940 |
产品别名
17374-26-4
Casein Kinase II Inhibitor I-CAS 17374-26-4-Calbiochem
TBB, TBBt, 4,5,6,7-Tetrabromobenzotriazole, 4,5,6,7-Tetrabromo-2-azabenzimidazole, CK2 Inhibitor
基本信息
| Empirical Formula【经验(实验)分子式】 | C6HBr4N3 |
| Molecular weight | 434.71 |
| MDL number | MFCD06411399 |
| General description【一般描述】 | A cell-permeable benzotriazolo compound that acts as a highly selective, ATP/GTP-competitive casein kinase II (CKII) inhibitor (IC50 = 900 nM and 1.6 µM for rat liver and human recombinant CKII, respectively) and DYRK (IC50<1 µM for DYRK1a). Specificity for CKII has been reported following the screening of 33 kinases, including PKA, Akt, PKC, MKK1, ERK2, p38, JNK, Lck, Lyn, and Syk. Also reported to inhibit NS3-associated viral helicase activity in hepatitis C virus (HCV) (IC50 = 20 and 60 µM using DNA and RNA substrates, respectively) and West Nile virus (WNV) (IC50 = 1.7 µM and 900 nM using DNA and RNA substrates, respectively). A cell-permeable benzotriazolo compound that acts as a higly selective, reversible, and ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 900 nM and 1.6 M, using rat liver and human recombinant CK2, respectively) and DYRK (IC50<1 M for DYRK1a). Its specificity has been demonstrated using a panel of 33 kinases, including PKA, PKB, PKC, MKK1, Erk2, p38, JNK, Lck, Lyn, and Syk. Also shown to inhibit NS3-associated viral helicase activities in HCV (IC50 = 20 and 60 M, using DNA and RNA substrate, respectively) and WNV (IC50 = 1.7 and 900 nM, using DNA and RNA substrate, respectively). A 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I in DMSO, is also available. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Product competes with ATP. Target IC50: 900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively; <1 µM for DYRK1a Reversible: yes |
| Warning【警告】 | Toxicity: Carcinogenic / Teratogenic (D) |
| Other Notes【其他说明】 | Borowski, P., et al. 2003. Eur. J. Biochem.270, 1645. Sarno, S., et al. 2003. Biochem. J.374, 639. Zien, P., et al. 2003. Biochem. Biophys. Res. Commun.306, 129. Ruzzene, M., et al. 2002. Biochem. J.364, 41. Sarno, S., et al. 2001. FEBS Lett.496, 44. Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun.208, 418. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥99% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 10 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13) |
| InChI key | OMZYUVOATZSGJY-UHFFFAOYSA-N |
| packaging【包装】 | 10 mg in Plastic ampoule Packaged under inert gas |
