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CCW16-C4-BocNH
产品别名
2361139-85-5
CCW16-C4-BocNH
Protein degrader building block for PROTAC research
tert-Butyl (4-(4-(4-(N-benzyl-2-chloroacetamido)phenoxy)phenoxy)butyl)carbamate
Crosslinker-E3 Ligase ligand conjugate
Template for synthesis of targeted protein degrader
RNF4-targeting building block
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C30H35ClN2O5 |
| Molecular weight | 539.06 |
| Application【应用】 | Protein degrader builiding block CCW16-C4-BocNH enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a RING finger protein 4 (RNF4)-recruiting ligand, an alkyl-chain crosslinker, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. |
| Other Notes【其他说明】 | Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC® Degraders for Targeted Protein Degradation Targeted Protein Degradation by Small Molecules |
| Legal Information【法律信息】 | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | 95% |
| form【形式】 | viscous liquid |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C(CCl)N(CC1=CC=CC=C1)C2=CC=C(C=C2)OC3=CC=C(OCCCCNC(OC(C)(C)C)=O)C=C3 O=C(CCl)N(CC1=CC=CC=C1)C2=CC=C(C=C2)OC3=CC=C(OCCCCNC(OC(C)(C)C)=O)C=C3 |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
