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CXCR4 Antagonist III-Calbiochem
| 产品编号： | 4156368 |
| 规格： | The CXCR4 Antagonist III controls the biological activity of CXCR4. This small molecule/inhibitor is primarily used for Biochemicals applications. |
| 包装规格： | 10 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
CXCR4 Antagonist III-Calbiochem
N2-(4-((3-(Cyclohexylamino)propylamino)methyl)benzyl)-N4-(piperidin-4-yl) quinazoline-2,4-diamine, 2HCl, Fusin Antagonist III
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C30H43N7 · 2HCl |
| Molecular weight | 574.63 |
| General description【一般描述】 | A cell-permeable quinazoline compound that acts as a potent and reversible CXCR4 antagonist (IC50 = 36.2 nM for SDF-1/CXCL12 binding to hCXCR4-transfected HEK293 membrane) with selectivity over closely related human chemokine receptors CXCR2, CCR2, CCR4 and CCR5 (IC50 >10 µM). Shown to inhibit CXCL12-induced Ca2+-mobilization and cell migration in hCXCR4-HEK293 cells (IC50 = 100.1 and 41 nM, respectively), and rapidly mobilize CXCR4+, CD34+ and CD133+ stem cells from bone marrow in C57BL/6 male mice (6 mg/kg, s.c). |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Reversible: yes |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (20°C). Stock solutions are stable for up to 6 months at -20°C. |
| Other Notes【其他说明】 | Wu, C.H., et al. 2012. Chem. Med. Chem.7, In press. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 25 mg/mL water: 25 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | C1(N=C(NCC2=CC=C(CNCCCNC3CCCCC3)C=C2)N=C4NC5CCNCC5)=C4C=CC=C1 |
| packaging【包装】 | 10 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 2 |
