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Granulocyte Macrophage Colony-Stimulating Factor, Mouse, Recombinant, E. coli

产品编号:4157253
规格:Granulocyte Macrophage Colony-Stimulating Factor, Mouse, Recombinant, E. coli, is a pleiotropic cytokine that can stimulate the proliferation, maturation, and function of hematopoietic cells.
包装规格:10 μG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
415725310 μG7540
产品别名

Granulocyte Macrophage Colony-Stimulating Factor, Mouse, Recombinant, E. coli

rmGM-CSF

产品性质
Quality Level【质量水平】
100
recombinant【重组】
expressed in E. coli
Assay【测定】
>97% (SDS-PAGE)
form【形式】
lyophilized
manufacturer/tradename
Calbiochem®
storage condition【储存条件】
OK to freeze
impurities【杂质】
≤1.0 EU/μg Endotoxin (EU/μg GM-CSF)
shipped in【运输】
ambient
storage temp.【储存温度】
−70℃
packaging【包装】
10 μg in Plastic ampoule
基本信息
General description【一般描述】
Recombinant, mouse granulocyte macrophage colony-stimulating factor expressed in E. coli. Pleiotropic cytokine that can stimulate the proliferation, maturation, and function of hematopoietic cells. Reported to improve the response rate to antibiotic therapy in cancer subjects. Activates JAK2 in a variety of cells.
Recombinant, mouse granulocyte macrophage colony-stimulating factor expressed in E. coli. Pleiotropic cytokine that stimulates the proliferation, maturation, and function of hematopoietic cells. Reported to improve the response rate to antibiotic therapy in cancer subjects. Activates JAK2 in a variety of cells. Target cells include macrophages, granulocytes, and eosinophils. GM-CSF is produced by many cell types, including endothelial cells, fibroblasts, and T-lymphocytes. It can be extracted from most tissues in concentrations exceeding that of serum levels. While many cells produce GM-CSF constitutively, levels of this lymphokine increase rapidly in response to endotoxin, phorbol esters, and certain antigens.
Biochem/physiol Actions【生化/生理作用】
ED₅₀ = 100-300 pg/ml as measured in a cell proliferation assay using a factor-dependent cell line, DA-3
Warning【警告】
Toxicity: Standard Handling (A)
Physical form【外形】
Lyophilized from sterile-filtered PBS containing 50 µg BSA/µg GM-CSF.
Reconstitution【重悬】
Reconstitute to a concentration of ≥10 µg/ml with sterile PBS containing ≥0.1% HSA or BSA.
Following reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short term storage. Avoid freeze/thaw cycles of solutions. Stock solutions are stable for 3 months at 4°C.
Other Notes【其他说明】
Anaissie, E.J., et al. 1996. Am. J. Med. 100, 15.
Watanabe, S., et al. 1996. J. Biol. Chem.271, 12681.
Moore, M.A. 1991. Annu. Rev. Immunol. 9, 159.
Nicola, N.A. 1989. Annu. Rev. Biochem. 58, 45.
Gough, N.M., et al. 1985. EMBO J. 4, 645.
Legal Information【法律信息】
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
安全信息
Storage Class Code【储存分类代码】
11 - Combustible Solids
WGK
WGK 1
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