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InSolution Akt Inhibitor X-CAS 925681-41-0-Calbiochem
| 产品编号： | 4157507 |
| 规格： | The InSolution |
| CAS NO： | 925681-41-0 |
| 包装规格： | 2 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4157507 | 2 MG | 2820 |
产品别名
925681-41-0
InSolution Akt Inhibitor X-CAS 925681-41-0-Calbiochem
10-(4'-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl, 4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl
4-(2-Chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine, HCl, 10-(4'-(N,N-Diethylamino)butyl)-2-chlorophenoxazine, HCl
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H25ClN2O · xHCl |
| Molecular weight | 344.88 (free base basis) |
| General description【一般描述】 | A cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity (complete inhibition <5 M) with minimal effect on PI 3-K, PDK1, or SGK1. Shown to suppress growth of Rh (rhabdomyosarcoma) cell lines (IC50 = 2-5 M), inhibit IGF-I-stimulated nuclear translocation of Akt, and prevent phosphorylation of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein. Unlike Akti1/2, the mode of inhibition is not PH domain-dependent. Also shown to induce neuronal autophagy in an Akt- and mTOR-independent manner and enhances the clearance of misfolded protein. The solid form of this compound is also available. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target Akt Reversible: yes |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Physical form【外形】 | A 20 mM (2 mg/262 µL) solution of Akt Inhibitor X (Cat. No. 124020) in H₂O. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C. |
| Other Notes【其他说明】 | Tsvetkov, A.S., et al. 2010. Proc. Natl. Acad. Sci. USA107, 16982. Thimmaiah, K.N., et al. 2005. J. Biol. Chem.280, 31924. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles protect from light |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| SMILES string | ClC(C=C1)=CC2=C1OC3=C(N2CCCCN(CC)CC)C=CC=C3 |
| packaging【包装】 | 2 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
