InSolution Hh/Gli Antagonist, GANT61-CAS 500579-04-4-Calbiochem

C₂₇H₃₅N₅

429.60

MFCD14635408

A cell-permeable hexahydropyrimidine compound that displays similar pharmacological property as, but is structurally disctinct from, GANT58 (>Cat. No. 373400). While both compounds act as downstream Hedgehog (Hh) pathway-selective blockers and target Gli-mediated gene transactivation with similar potency (IC₅₀ ~5 µM) in SAG-stimulated Shh-L2 cells, GANT61 does exhibit better in vivo antitumor efficacy, presumably due to its superior pharmacokinetics, and only GANT61, but not GANT58, is shown to inhibit Gli DNA binding in HEK293 cells. The solid form of this compound (Cat. No. 373401) is also available.

Cell permeable: yes
Primary Target
Gli1 and Gli2

Toxicity: Irritant (B)

A 25 mM (2 mg/186 µL) solution of Hh/Gli Antagonist, GANT61 (Cat. No. 373401) in DMSO.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

liquid

Calbiochem^®

OK to freeze
avoid repeated freeze/thaw cycles
desiccated (hygroscopic)
protect from light

dry ice

−20℃

CN(C)C1=CC=CC=C1CN2CCCN(CC3=CC=CC=C3N(C)C)C2C4=CC=NC=C4

2 mg in Glass bottle
Packaged under inert gas

10 - Combustible liquids

WGK 2

188.6 °F - (refers to pure substance)

87 ℃ - (refers to pure substance)