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InSolution PTP1B Inhibitor-Calbiochem
| 产品编号： | 4157518 |
| 规格： | The InSolution |
| 包装规格： | 2 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
InSolution PTP1B Inhibitor-Calbiochem
PTP Inhibitor XXII
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H19Br2N3O7S3 |
| Molecular weight | 741.45 |
| General description【一般描述】 | A cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop. |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes IC50 = 4 and 8 µM for PTP1B403 and PTP1B298, respectively Reversible: yes |
| Warning【警告】 | Toxicity: Irritant (B) |
| Physical form【外形】 | A 10 mM (2 mg/270 µl) solution of PTP1B Inhibitor (Cat. No. 539741) in DMSO. |
| Reconstitution【重悬】 | Following initial thaw, aliquot and freeze (-20°C). |
| Other Notes【其他说明】 | Wiesmann, C., et al. 2004. Nat. Struct. Mol. Biol.11, 730. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | liquid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze avoid repeated freeze/thaw cycles desiccated (hygroscopic) protect from light |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 2 mg in Glass bottle Packaged under inert gas |
