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Kaempferol-CAS 520-18-3-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4157663 | 25 MG | 1940 |
产品别名
520-18-3
Kaempferol-CAS 520-18-3-Calbiochem
3,4',5,7-Tetrahydroxyflavone
基本信息
| Empirical Formula【经验(实验)分子式】 | C15H10O6 |
| Molecular weight | 286.24 |
| MDL number | MFCD00016938 |
| General description【一般描述】 | A cell-permeable phytoestrogen that inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Offers protection against Aβ25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Blocks the Aβ-induced activation of caspase-2, -3, -8, and -9, and reduces NMDA-induced neuronal apoptosis. Reported to be a potent inhibitor of monoamine oxidases. Acts as an inhibitor of COX-1 activity (IC50 = 180 µM), and of transcriptional activation of COX-2 (IC50<15 µM). A cell-permeable, phytoestrogen that offers protection against Aβ25-35-induced cell death in neonatal cortical neurons. Its protective effects are comparable to that of estradiol. Reduces the activation of caspases 2, 3, 8, and 9 by Aβ. Inhibits topoisomerase I-catalyzed DNA religation in HL-60 cells. Also shown to protect against NMDA-induced neuronal toxicity in vitro in cultured rat cortical neurons. Acts as an inhibitor of cyclooxygenases (COX-1, IC50 = 180 µM) and COX-2 (IC50 = ~15 µM). |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Primary Target Topoisomerase I-catalyzed DNA religation in HL-60 cells Target IC50: 180 µM against COX-1 activity Product does not compete with ATP. Reversible: no |
| Warning【警告】 | Toxicity: Carcinogenic / Teratogenic (D) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Wang, C.N., et al. 2001. J. Biol. Chem.276, 5287. Sloley, B.D., et al. 2000. J. Pharm. Pharmacol.52, 451. Wang, H., et al. 2000. Phytomedicine7, 15. Liang, Y.C., et al. 1999. Carcinogenesis20, 1945. Roth, A., et al. 1999. J. Neurosci. Res.57, 399. Boege, F., et al. 1996. J. Biol. Chem.271, 2262. Constantinou, A., et al. 1995. J. Nat. Prod.58, 217. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | yellow |
| solubility【溶解性】 | ethanol: 20 mg/mL DMSO: 25 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H |
| InChI key | IYRMWMYZSQPJKC-UHFFFAOYSA-N |
| packaging【包装】 | 25 mg in Glass bottle Packaged under inert gas |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 |
| Precautionary Statements | P264 - P270 - P301 + P312 - P501 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
