MultiScreen IP Filter Plate, 0.45 μm, clear, non-sterile

32039006

NB.22

Filter Code: IP
Increasing drug candidate predictability earlier in the discovery pipeline using non-cell-based assays can improve candidate throughput during the ADME stage. Non-cell-based permeability assays are predictive models for oral absorption of development candidates.

MultiScreen Permeability, MultiScreen-IP, and MultiScreen Acceptor plates support artificial membrane strategies for predicting passive transport.

Membranes have uniform pore structure and density for reliable transport:
- Individual wells minimize candidate cross-talk
- Compatibility with automated liquid handling systems increases throughput

Permeability Assay:
- The MultiScreen Permeability plate has a polycarbonate membrane, which supports a hexane/hexadecane artificial layer for permeability assays.1

PAMPA Assay:
- The MultiScreen-IP plate has a hydrophobic PVDF membrane, which supports a lipid bilayer for PAMPA asays.2,3

MultiScreen Acceptor Plate:
- The MultiScreen Acceptor plate can be used with either plate to capture passively transported compounds. Constructed of 100% PTFE, the plate can improve LC/MS results depending on the charge of the small molecules being evaluated.

Research Category
Assays

Protein

Color Code: 透明

Automation Compatible: No

Immobilon is a registered trademark of Merck KGaA, Darmstadt, Germany
MULTISCREEN is a registered trademark of Merck KGaA, Darmstadt, Germany

PVDF membrane (hydrophobic)
acrylic
flat bottom wells

400

non-sterile

MultiScreen^®

hydrophobic
lid

MultiScreen^®

parallel artificial membrane permeation assay (PAMPA): suitable

96 wells

300 μL

50-250 μL

Immobilon^®-P

0.45 μm pore size

sample volume: 50-250 μL (per well)

high binding surface

ambient