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Neuronal Differentiation Inducer III-CAS 832115-62-5-Calbiochem
产品编号: | 4168002 |
规格: | A cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 μM) in various stem/progenitor cells. |
CAS NO: | 832115-62-5 |
包装规格: | 10 MG |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
832115-62-5
Neuronal Differentiation Inducer III-CAS 832115-62-5-Calbiochem
N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide, Isx
Isx, N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide
基本信息
Empirical Formula【经验(实验)分子式】 | C11H10N2O2S |
Molecular weight | 234.27 |
General description【一般描述】 | A cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 µM) in various stem/progenitor cells. Induces insulin expression, and activates ERK signaling and histone acetylation in MIN6 pancreatic β cells. The underlying excitation-neurogenesis signaling is comprised of, at least in part, an initial NMDA receptor- and L-type chanenels-mediated Ca2+ influx, followed by an activation of CaMKII, phosphorylation/nuclear export of the MEF2 repressor HDAC5, the subsequent de-repression of MEF2, and the eventual activation of the HDAC-MEF2 epigenetic/transcriptional regulatory network. |
Warning【警告】 | Toxicity: Standard Handling (A) |
Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
Other Notes【其他说明】 | Dioum, E.M., et al. 2011. Proc. Natl. Acad. Sci. USA108, 20713. Zhang, L., et al. 2011. Differentiation81, 233. Sadek, H., et al. 2008. Proc. Natl. Acad. Sci. USA105, 6063. Schneider, J.W., et al. 2008. Nat. Chem. Biol.4, 408. |
Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
Quality Level【质量水平】 | 100 |
Assay【测定】 | ≥95% (HPLC) |
form【形式】 | solid |
manufacturer/tradename | Calbiochem® |
storage condition【储存条件】 | OK to freeze protect from light |
color【颜色】 | off-white |
solubility【溶解性】 | ethanol: 3 mg/mL DMSO: 5 mg/mL |
shipped in【运输】 | ambient |
storage temp.【储存温度】 | 2-8℃ |
packaging【包装】 | 10 mg in Plastic ampoule Packaged under inert gas |
安全信息
Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
WGK | WGK 2 |