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Pam3Cys-Ser-(Lys)4, Hydrochloride
产品别名
112208-00-1
Pam3Cys-Ser-(Lys)4, Hydrochloride
(S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys4-OH, 3HCl, P3CSK4, 3HCl, Pam3Cys-SK4, 3HCl, Pam3CSK4, TLR1/TLR2 Agonist I
基本信息
| Empirical Formula【经验(实验)分子式】 | C81H156N10O13S · 3HCl |
| Molecular weight | 1619.61 |
| General description【一般描述】 | A cell-permeable, water-soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide, and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. Acts as a selective agonist of TLR2 (Toll-like receptor 2). A cell-permeable, water-soluble, synthetic, cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation, and activates ERK1/2 and MEK1/2. Acts as a selective TLR-2 (Toll-like receptor 2) agonist. |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Avoid freeze/thaw cycles of solutions. |
| Other Notes【其他说明】 | Barrenschee, M., et al. 2010. PLoS One.5, e13889. Zahringer, U., et al. 2008. Immunology.213, 205. Toshchakov, V., et al. 2002. Nat. Immunol.3, 392. Muller, M.R., et al. 2001. Immunology103, 49. Vergne, I., and Cezanne, L. 1999. Eur. J. Biochem.264, 369. Diaz-Guerra, M.J., et al. 1996. J. Biol. Chem.271, 30114. Offermanns, S., et al. 1992. Biochem. J.282, 551. Seifert, R., et al. 1990. Biochem. J.267, 795. Hoffmann, P., et al. 1989. Biol. Chem. Hoppe. Seyler.370, 575. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Assay【测定】 | ≥90% (HPLC) |
| Quality Level【质量水平】 | 100 |
| form【形式】 | lyophilized solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated |
| solubility【溶解性】 | water: 2 mg/mL |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C81H156N10O13S/c1-4-7-10-13-16-19-22-25-28-31-34-37-40-55-73(93)86-72(65-105-64-66(104-75(95)57-42-39-36-33-30-27-24-21-18-15-12-9-6-3)63-103-74(94)56-41-38-35-32-29-26-23-20-17-14-11-8-5-2)80(100)91-71(62-92)79(99)89-68(52-44-48-59-83)77(97)87-67(51-43-47-58-82)76(96)88-69(53-45-49-60-84)78(98)90-70(81(101)102)54-46-50-61-85/h66-72,92H,4-65,82-85H2,1-3H3,(H,86,93)(H,87,97)(H,88,96)(H,89,99)(H,90,98)(H,91,100)(H,101,102)/t66?,67-,68-,69-,70-,71-,72-/m0/s1 |
| InChI key | OEDPHAKKZGDBEV-GFPBKZJXSA-N |
| packaging【包装】 | 2 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
