Phospholipase C Activator, m-3M3FBS-CAS 200933-14-8-Calbiochem

C₁₆H₁₆F₃NO₂S

343.36

MFCD00095824

NA.77

A novel sulfonamide compound that acts as a cell-permeable and specific activator of phospholipase C (PLC). Shown to stimulate the PLC-mediated intracellular Ca²⁺ release, inositol phosphates production, and superoxide generation in various cell types. It activates all PLC isotypes (β2, β3, γ1, γ2, and δ1) in vitro, but not heterotrimeric G proteins, PI 3-kinase, or PLD.
A cell-permeable and specific activator of phospholipase C (PLC). Reported to stimulate PLC-mediated intracellular Ca²⁺ release, inositol phosphate production, and superoxide generation in various cell types. Activates all PLC isotypes (β2, β3, γ1, &gamma2, and δ1) in vitro, but does not exhibit any effect on heterotrimeric G proteins, PI 3-kinase, or phospholipase D.

Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Primary Target
Phospholipase C (PLC)

Toxicity: Carcinogenic / Teratogenic (D)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. Avoid freeze/thaw cycles of solutions.

Bae, Y.S., et al. 2003. Mol. Pharmacol.63, 1043.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥95% (HPLC)

solid

Calbiochem^®

OK to freeze
protect from light

off-white

DMSO: 7 mg/mL

ambient

2-8℃

1S/C16H16F3NO2S/c1-10-7-11(2)15(12(3)8-10)23(21,22)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3

ZIIUUSVHCHPIQD-UHFFFAOYSA-N

10 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 3