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Protein Methyltransferase Inhibitor, AMI-5-CAS 17372-87-1-Calbiochem
| 产品编号： | 4168653 |
| 规格： | The Protein Methyltransferase Inhibitor, AMI-5, also referenced under CAS 17372-87-1, controls the biological activity of Protein Methyltransferase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. |
| CAS NO： | 17372-87-1 |
| 包装规格： | 50 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4168653 | 50 MG | 1940 |
产品别名
17372-87-1
Protein Methyltransferase Inhibitor, AMI-5-CAS 17372-87-1-Calbiochem
Disodium-2-(2,4,5,7-tetrabromo-3-oxido-6-oxoxanthen-9-yl)benzoate, trihydrate, A(K)MI-5, PRMT Inhibitor III
基本信息
| Empirical Formula【经验(实验)分子式】 | C29H6Br4Na2O5 · 3H2O |
| Molecular weight | 854.00 |
| MDL number | MFCD00005040 |
| General description【一般描述】 | A xanthenyl compound that inhibits the activities of protein arginine methyltransferases (PRMT) Hmt1p, PRMT1/3/4/6 (IC50 against yeast Hmt1p & human PRMT1 = 0.78 & 1.41 µM, respectively), as well as histone lysine methyltransferases (HMTases) SET7 and DOT1 in an AdoMet/SAM- (S-adenosylmethionine) competitive manner. Although SAM-competitive inhibitors generally exhibit broad activity against and are non-selective toward most SAM-utilizing enzymes, AMI-5 is known to be inactive against at least two HMTases (Suv39H1 & Suv39H2). |
| Warning【警告】 | Toxicity: Irritant (B) |
| Other Notes【其他说明】 | Cheng, D., et al. 2004. J. Biol. Chem.279, 23892. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥90% |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze desiccated (hygroscopic) protect from light |
| color【颜色】 | red-brown |
| solubility【溶解性】 | water: 50 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C20H8Br4O5.2Na/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25;;/h1-6,25H,(H,27,28);;/q;2*+1/p-2 |
| InChI key | SEACYXSIPDVVMV-UHFFFAOYSA-L |
| packaging【包装】 | 50 mg in Plastic ampoule Packaged under inert gas |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H317 - H319 |
| Precautionary Statements | P261 - P264 - P272 - P280 - P302 + P352 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Sens. 1 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Flash Point(F)【闪点(F)】 | 376.9 °F - Pensky-Martens closed cup |
| Flash Point(C)【闪点(C)】 | 191.6 ℃ - Pensky-Martens closed cup |
