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R-Spondin 4, Mouse, Recombinant
产品别名
R-Spondin 4, Mouse, Recombinant
Cristin 4
产品性质
| Assay【测定】 | ≥95% (SDS-PAGE) |
| Quality Level【质量水平】 | 100 |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze |
| impurities【杂质】 | <1.0 EU/μg protein Endotoxin |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| packaging【包装】 | 25 μg in Glass bottle |
基本信息
| General description【一般描述】 | Recombinant, mouse R-Spondin 4 consisting of amino acids 19-228 and expressed in Chinese Hamster Ovary cells. Able to induce activation of β-catenin response in a Luciferase assay using HEK293T human embryonic kidney cells. R-spondin 4 is useful as a positive modulator of Wnt/β signaling. |
| Biochem/physiol Actions【生化/生理作用】 | ED₅₀ = 5-20 ng/ml in the presence of 10 ng/ml rmWnt-3a, as measured by induction of activation of β-catenin response in a Topflash Luciferase assay using HEK293T human embryonic kidney cells. |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Physical form【外形】 | Lyophilized from 0.2 µm sterile-filtered PBS, NaCl, EDTA, BSA. |
| Reconstitution【重悬】 | Reconstitute to 200 µg/ml in PBS. |
| Other Notes【其他说明】 | Hendrickx, M. and L. Leyns. 2008. Develop. Growth Differ.50, 229. Ishii, Y., et al. 2008. J. Invest. Dermatol.128, 867. Kim, K.A., et al. 2008. Mol. Biol. Cell19, 2588. Binnerts, M.E., et al. 2007. Proc. Natl. Acad. Sci. USA104 14700. Nam, J.S., et al. 2007. Gene Expr. Patterns7, 306. Pemberton, T.J., et al. 2007. Dev. Dyn.236, 2245. Bergmann, C., et al. 2006. Am. J. Hum. Genet.79, 1105. Blaydon, D.C., et al. 2006. Nat. Genet.38, 1245. Nam, J.S., et al. 2006. J. Biol. Chem.281, 13247. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
