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Riluzole-CAS 1744-22-5-Calbiochem
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4168844 | 50 MG | 1590 |
产品别名
1744-22-5
Riluzole-CAS 1744-22-5-Calbiochem
2-Amino-6-(trifluoromethoxy)benzothiazole, PK 26124
基本信息
| Empirical Formula【经验(实验)分子式】 | C8H5F3N2OS |
| Molecular weight | 234.20 |
| MDL number | MFCD00210213 |
| General description【一般描述】 | A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. Reported to function as a polyglutamine aggregation inhibitor and stimulate the synthesis of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell-derived neurotrophic factor (GDNF) in mouse astrocyte cultures. Offers neuroprotection, slows disease progression in amyotrophic lateral sclerosis (ALS) patients, and prolongs survival in animal models of Huntington′s disease (HD). A cell-permeable benzothiazole compound that potently inhibits glutamate release and blocks Na+ channels. Shown to function as a polyglutamine aggregation inhibitor and stimulates the synthesis of NGF, BDNF, and GDNF in mouse astrocyte cultures. Reported to offer neuroprotection, slow down disease progression in ALS (amyotrophic lateral sclerosis) patients, and prolong the lifespan of animal models of HD (Huntington’s disease). |
| Biochem/physiol Actions【生化/生理作用】 | Cell permeable: yes Product does not compete with ATP. Reversible: no Primary Target Inhibits glutamate release and blocks Na+ channels |
| Warning【警告】 | Toxicity: Toxic (F) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Heiser, V., et al. 2002. Proc. Natl. Acad. Sci. USA99, 16400. Schiefer, J., et al. 2002. Mov. Disord.17, 748. Mizuta, I., et al. 2001. Neurosci. Lett.310, 117. Louvel, E., et al. 1997. Trends Pharmacol. Sci.18, 196. Mizoule, J., et al. 1985. Neuropharmacology24, 767. Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥97% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | HCl: 0.1 N DMSO: 40 mg/mL |
| cation traces【痕量阳离子】 | heavy metals: ≤20 ppm |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13) |
| InChI key | FTALBRSUTCGOEG-UHFFFAOYSA-N |
| packaging【包装】 | 50 mg in Alu drum Packaged under inert gas |
安全信息
| Pictograms【象形图】 | GHS06 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H300 |
| Precautionary Statements | P264 - P270 - P301 + P310 - P405 - P501 |
| Hazard Classifications【危险分类】 | Acute Tox. 2 Oral |
| Storage Class Code【储存分类代码】 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 3 |
