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Sphingosine Kinase 1 Inhibitor, SKI-178-Calbiochem
产品别名
Sphingosine Kinase 1 Inhibitor, SKI-178-Calbiochem
Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide, N'-(1E)-1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H22N4O4 |
| Molecular weight | 394.42 |
| General description【一般描述】 | A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >>25 µM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8 µM). |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Other Notes【其他说明】 | Hengst, J.A., et al. 2010. .Bioorg. Med. Chem. Lett.20, 7498 |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Assay【测定】 | ≥92% (HPLC) |
| Quality Level【质量水平】 | 100 |
| form【形式】 | powder |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | off-white |
| solubility【溶解性】 | DMSO: 100 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 10 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 1 |
