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Survivin Antagonist, S12-Calbiochem
| 产品编号： | 4169495 |
| 规格： | The Survivin Antagonist, S12 controls the biological activity of Survivin. |
| 包装规格： | 10 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Survivin Antagonist, S12-Calbiochem
Survivin Inhibitor II, 3-(2-(benzo[d][1,3]dioxol-5-yl)-2-oxoethyl)-5-bromo-3-hydroxyindolin-2-one
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C17H12BrNO5 |
| Molecular weight | 390.18 |
| MDL number | MFCD00117860 |
| General description【一般描述】 | A cell-permeable hydroxyindolinone compound that acts as a selective antagonist of survivin. Induces mitotic arrest and blocks cell cycle at G2/M phase (~40 µM in HeLA cells) leading to apoptotic cell death. Shown to bind to a specific cavity adjacent to the interface involved in the dimerization of survivin. Binding is specific only to native survivin and does not affect any mutant forms. Inhibits HCT116 cell proliferation independently of their p53 status and reduces tumor volume in xenograft models in a dose-dependent manner (5 to 15 mg/kg). |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. |
| Other Notes【其他说明】 | Berezov, A., et al. 2011. Oncogene31, 1938. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | white |
| solubility【溶解性】 | DMSO: 50 mg/mL, nearly colorless |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | O=C(CC1(C(C=C(Br)C=C2)=C2NC1=O)O)C3=CC(OCO4)=C4C=C3 |
| packaging【包装】 | 10 mg in Glass bottle Packaged under inert gas |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
