Swinholide A, Theonella swinhoei-Calbiochem

C₇₈H₁₃₂O₂₀

1389.87

A dimeric dilactone macrolide that is cytotoxic to a variety of cancer cell lines in vitro. Disrupts the actin cytoskeleton by sequestering actin dimers with a binding stoichiometry of 1:1, and rapidly severing F-actin. Also possesses antifungal properties.
A dimeric dilactone macrolide isolated from the marine sponge Theonella swinhoei. Cytotoxic to a variety of cancer cell lines in vitro. Disrupts the actin cytoskeleton by sequestering actin dimers with a binding stoichiometry of 1:1, and rapidly severing F-actin. Also possesses antifungal activity.

Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Disrupts the actin cytoskeleton

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Saito, S.Y., et al. 1998. J. Biochem. (Tokyo) 123, 571.
Bubb, M.R., et al. 1995. J. Biol. Chem. 270, 3463.
Kobayashi, M., et al. 1994. Chem. Pharm. Bull. 42, 19.
Doi, M., et al. 1991. J. Org. Chem. 56, 3629.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (HPLC)

oil

Calbiochem^®

OK to freeze
protect from light

colorless

acetone: soluble
ethanol: soluble

ambient

−20℃

10 μg in Plastic ampoule
Packaged under inert gas

H413

P273 - P501

Aquatic Chronic 4

10 - Combustible liquids

WGK 3