Syk Inhibitor III-CAS 1485-00-3-Calbiochem

C₉H₇NO₄

193.16

MFCD00014575

A cell-permeable nitrostyrene compound that acts as a selective inhibitor of Syk kinase activity (IC₅₀ = 2.5 µM). It inhibits Src only at much higher concentrations (IC₅₀ = 29.3 µM) and exhibits little effect against Fak and JAK2. Shown to potently inhibit platelet aggregation induced by various stimulators, including U46619, ADP, arachidonic acid, collagen, thrombin, ionophore A23187, and PDBu (IC₅₀ ranges from 2.1 to 25.9 µM).

Cell permeable: yes
Primary Target
Syk
Target IC₅₀: 2.5 µM against Syk kinase activity
Product does not compete with ATP.
Reversible: no

Toxicity: Irritant (B)

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Wang, W.Y., et al. 2006. Mol. Pharmacol.70, 1380.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥98% (GC)

solid

Calbiochem^®

OK to freeze
protect from light

yellow to brown

DMSO: 25 mg/mL (Use only fresh DMSO.)

ambient

−20℃

1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3-

KFLWBZPSJQPRDD-ARJAWSKDSA-N

50 mg in Plastic ampoule
Packaged under inert gas

GHS07

Warning

H315 - H319

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

Eye Irrit. 2 - Skin Irrit. 2

11 - Combustible Solids

WGK 3