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Hepatitis C virus core antigen
| 产品编号： | 3095826 |
| 规格： | ~1 mg/mL, ≥95% (SDS-PAGE), recombinant, expressed in E. coli |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
基本信息
| MDL number | MFCD02264926 |
| NACRES | NA.32 |
| General description【一般描述】 | Hepatitis C virus core antigen (HCV-cAg) is a well-preserved antigenic protein of the internal capsid. Hepatitis C virus glycoprotein 1 (HCVgp1), also referred to as polyprotein, is crucial for the induction of double-membrane vesicles, sites of HCV RNA amplification. The amino terminal of polyprotein contains the structural proteins core, envelope protein 1 (E1) and E2. The proteolytic cleavage of polyprotein results in the formation of 10 mature viral proteins which are needed for viral replication and assembly. amino acids 2-192 of HCV polyprotein |
| Specificity【特异性】 | Reacts strongly with human HCV positive serum. |
| Application【应用】 | Hepatitis core antigen (HCA) has been used as an analyte in enzyme-linked immunosorbent assay (ELISA) to study the mechanism of bovine serum albumin (BSA) blocking in common ELISA protocols. |
| Biochem/physiol Actions【生化/生理作用】 | Hepatitis C virus core antigen (HCV-cAg) may be a less expensive way to diagnose active hepatitis C virus (HCV) infection in the hemodialysis (HD) population. Positive control for HCV antibodies. |
| Other Notes【其他说明】 | HCV core antigen [2-192]-Galactosidase-tagged at the N-terminus. |
| Physical form【外形】 | Solution in 8 M Urea, 20 mM Tris-HCl, pH 8.0, 10 mM 2-mercaptoethanol. |
产品性质
| Quality Level【质量水平】 | 200 |
| recombinant【重组】 | expressed in E. coli |
| Assay【测定】 | ≥95% (SDS-PAGE) |
| mol wt【分子量】 | 22 kDa (plus 114 kDa galactosidse) |
| concentration【浓度】 | ~1 mg/mL |
| UniProt accession no.【UniProt登记号】 | G9G988 L7S4V3 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | hepatitis C virus ... HCVgp1(951475) human ... HBVgp4(944568) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
