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IMS2186
产品别名
1031206-36-6
IMS2186
3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H16O4 |
| Molecular weight | 296.32 |
| MDL number | MFCD12912419 |
| PubChem Substance ID【PubChem化学物质编号】 | 329815315 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | IMS2186 is an anti-proliferative and anti-angiogenic agent. Apparently IMS2186 blocks the cell cycle at G2 and inhibits the production of PGE2/TNF-α. IMS2186 inhibits cell growth in vitro in tumor cells, non-transformed fibroblasts, and retinal pigment epithelial cells. IMS2186 inhibits angiogenesis (IC50 = 0.1 μM) and cell migration. Intraocular injection of IMS2186 could be a long-lasting effective treatment for CNV (choroidal neovascularization) in AMD (age-related macular degeneration) with a reduction in scarring and related visual loss. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | DMSO: >20 mg/mL |
| storage temp.【储存温度】 | room temp |
| SMILES string | COc1ccc(cc1O)\C=C2/COc3ccc(C)cc3C2=O |
| InChI | 1S/C18H16O4/c1-11-3-5-16-14(7-11)18(20)13(10-22-16)8-12-4-6-17(21-2)15(19)9-12/h3-9,19H,10H2,1-2H3/b13-8+ |
| InChI key | BZCADTHMZLYKAR-MDWZMJQESA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS09 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H400 |
| Precautionary Statements | P273 |
| Hazard Classifications【危险分类】 | Aquatic Acute 1 |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
