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Monoclonal Anti-Interleukin-4 antibody produced in mouse
| 产品编号： | 3147080 |
| 规格： | clone 3010, purified immunoglobulin, lyophilized powder |
| 包装规格： | 500 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-Interleukin-4 antibody produced in mouse
Anti-IL-4
基本信息
| MDL number | MFCD00212213 |
| NACRES | NA.41 |
| General description【一般描述】 | Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signalling stimulated by IL-4 leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. Through these pathways, IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Anti-tumor effects of IL-4 have been reported in cancers of breast, liver and renal cells Anti-Interleukin-4 specifically recognizes human interleukin-4. |
| Immunogen【免疫原】 | purified, E. coli-derived recombinant human interleukin-4. |
| Application【应用】 | Anti-Interleukin-4 antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For ELISA, a working concentration of 4 μg/ml is recommended. |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 3010, monoclonal |
| form【形式】 | lyophilized powder |
| species reactivity | human |
| technique(s) | capture ELISA: suitable western blot: 1-2 μg/mL |
| isotype【同位素/亚型】 | IgG1 |
| UniProt accession no.【UniProt登记号】 | P05112 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... IL4(3565) |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
