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NN414
产品别名
279215-43-9
NN414
6-Chloro-3-[[1-methylcyclopropyl]amino]-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide
Tifenazoxide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C9H10ClN3O2S2 |
| Molecular weight | 291.78 |
| MDL number | MFCD18711369 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825549 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | NN414 is a potent Kir6.2/SUR1 selective K-ATP channel opener. Activation of the pancreatic Kir6.2/SUR KATP channels inhibits insulin release to induce beta cell rest, reducing the workload of the beta cell which is thought may prove beneficial for patients with type 2 diabetes. A recent study found that NN414 also triggered burst-like discharges in substantia nigra dopamine neurons. These K-ATP channel enabled burst-like discharges are associated with novelty-dependent exploratory behavior and may also have relevance to Parkinson′s disease. |
| Features and Benefits【特点和优势】 | This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 15 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CC1(CC1)NC2=NS(=O)(=O)c3sc(Cl)cc3N2 |
| InChI | 1S/C9H10ClN3O2S2/c1-9(2-3-9)12-8-11-5-4-6(10)16-7(5)17(14,15)13-8/h4H,2-3H2,1H3,(H2,11,12,13) |
| InChI key | KYSFUHHFTIGRJN-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
