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SMI-4a
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3240496 | 10 MG | 1580 | 2-5天 | 4-6周 |
产品别名
438190-29-5
SMI-4a
(Z)-5-(3-Trifluoromethylbenzylidene)thiazolidine-2,4-dione
(5Z)-5-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C11H6F3NO2S |
| Molecular weight | 273.23 |
| MDL number | MFCD01152003 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825328 |
| Biochem/physiol Actions【生化/生理作用】 | SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM for Pim-1 compared to an IC50 of 100 nM for Pim-2 and with little or no activity against a panel of 50 other kinases tested. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: >10 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | FC(F)(F)c1cccc(\C=C2/SC(=O)NC2=O)c1 |
| InChI | 1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5- |
| InChI key | NGJLOFCOEOHFKQ-YVMONPNESA-N |
| packaging【包装】 | 10, 50 mg in glass bottle |
