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SYUIQ-5
产品别名
188630-47-9
SYUIQ-5
N′-(10H-Indolo [3,2-b]quinolin-11-yl)-N, N-dimethyl-propane-1,3-diamine
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H22N4 |
| Molecular weight | 318.42 |
| MDL number | MFCD17215940 |
| PubChem Substance ID【PubChem化学物质编号】 | 329824555 |
| NACRES | NA.77 |
| Application【应用】 | SYUIQ-5 may be used in autophagy and DNA damage-inducing cell signaling studies. |
| Biochem/physiol Actions【生化/生理作用】 | SYUIQ-5 is a Cryptolepine derivative, which induces and stabilizes G-quadruplexes. In CNE2 and HeLa cancer cells SYUIQ-5 triggers rapid and potent telomere DNA damage through TRF2 delocalization from telomeres and induces cell death by autophagy. In low concentration the compound caused senescence and telomere shortening. It is a potent cytotoxic agent. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | yellow |
| solubility【溶解性】 | DMSO: ≥20 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CN(C)CCCNc1c2ccccc2nc3c4ccccc4[nH]c13 |
| InChI | 1S/C20H22N4/c1-24(2)13-7-12-21-18-14-8-3-5-10-16(14)22-19-15-9-4-6-11-17(15)23-20(18)19/h3-6,8-11,23H,7,12-13H2,1-2H3,(H,21,22) |
| InChI key | CTDCVGDSVHUYMA-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS09 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H400 |
| Precautionary Statements | P273 |
| Hazard Classifications【危险分类】 | Aquatic Acute 1 |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 2 |
