AH6809

C₁₇H₁₄O₅

298.29

MFCD08056083

329770690

NA.77

AH6809 has been used:

• as a prostaglandin E2 receptor 1 & 2 (EP1/2) antagonist to analyze its effects on cyclooxygenase-2 /prostaglandin E2 (COX-2/PGE2) signaling in the angiogenic feedback of endothelial cells to hypoxia
• as an EP2 antagonist to study its effects on tumor angiogenesis in human prostate cancer cell lines
• as an EP2 antagonist to analyze its effects on overexpression of amyloid precursor protein (APP)

AH6809 plays a role in antagonizing the proliferation of non-small cell lung cancer cell lines.
DP/EP prostanoid receptor antagonist; has the highest affinity for DP receptors, but also acts as a weak antagonist at murine EP₁ and EP₂ prostanoid receptors.

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

100

≥98%

crystalline solid or supercooled liquid

ethanol: soluble 2.5 mg/mL
DMSO or DMF: soluble 8 mg/mL

CC(C)Oc1ccc2c(Oc3ccc(cc3C2=O)C(O)=O)c1

1S/C17H14O5/c1-9(2)21-11-4-5-12-15(8-11)22-14-6-3-10(17(19)20)7-13(14)16(12)18/h3-9H,1-2H3,(H,19,20)

AQFFXPQJLZFABJ-UHFFFAOYSA-N

5 mg in glass bottle

13 - Non Combustible Solids

WGK 3

Eyeshields, Gloves, type N95 (US)