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Anle138b
产品别名
882697-00-9
Anle138b
Anle 138b
3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole
5-(1,3-Benzodioxol-5-yl)-3-(3-bromophenyl)-1H-pyrazole
CID 44608289
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C16H11BrN2O2 |
| Molecular weight | 343.17 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825932 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Anle138b is a fluorescent inhibitor of α-synuclein and prion-protein (PrPSc) aggregation that reduces the progression of prion and Parkinson′s disease in animal models. Anle138b extends the survival of mice infected with prions. Anle138b strongly inhibits BSE-derived and human prions. The fluorescence strongly increases upon binding with α-synuclein fibrils. Apparently, Anie138b binds to hydrophobic pockets in the fibrils. Anle138b, an oligomer modulator, inhibits neuronal degeneration. It rescues neurons from the aggregation effects of α-synuclein. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to beige |
| solubility【溶解性】 | DMSO: 20 mg/mL, clear |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | BrC1=CC(C2=CC(C3=CC(OCO4)=C4C=C3)=NN2)=CC=C1 |
| InChI | 1S/C16H11BrN2O2/c17-12-3-1-2-10(6-12)13-8-14(19-18-13)11-4-5-15-16(7-11)21-9-20-15/h1-8H,9H2,(H,18,19) |
| InChI key | RCQIIBJSUWYYFU-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H315 - H319 - H335 |
| Precautionary Statements | P302 + P352 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3 |
| Target Organs【靶器官】 | Respiratory system |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
