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Anti-AKT1 (Ab-450) antibody produced in rabbit
产品别名
Anti-AKT1 (Ab-450) antibody produced in rabbit
Anti-v-akt murine thymoma viral oncogene homolog 1 antibody produced in rabbit
Anti-PKB antibody produced in rabbit
Anti-AKT antibody produced in rabbit
Anti-MGC99656 antibody produced in rabbit
Anti-PKB-ALPHA antibody produced in rabbit
基本信息
| MDL number | MFCD03096597 |
| NACRES | NA.41 |
| Immunogen【免疫原】 | Peptide sequence around aa. 448-452 (T-I-T-P-P), according to the protein AKT1. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~60 kDa |
| species reactivity | rat, human, mouse |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100 indirect immunofluorescence: 1:100-1:200 western blot: 1:500-1:1000 |
| isotype【同位素/亚型】 | IgG |
| immunogen sequence【免疫原序列】 | (T-I-T-P-P) |
| NCBI accession no.【NCBI登记号】 | NP_001014431.1 |
| UniProt accession no.【UniProt登记号】 | P31749 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... AKT1(207) |
产品说明
| Target description【目标描述】 | General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. |
安全信息
| Storage Class Code【储存分类代码】 | 10 - Combustible liquids |
| WGK | WGK 1 |
