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AR-A014418
| 产品编号： | 3410050 |
| 规格： | ≥98% (HPLC), solid |
| CAS NO： | 487021-52-3 |
| 包装规格： | 5 MG，25 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3410050 | 5 MG | 2120 | 2-5天 | 4-6周 | |
| 3410050 | 25 MG | 6620 | 2-5天 | 4-6周 |
产品别名
487021-52-3
AR-A014418
N-(4-Methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C12H12N4O4S |
| Molecular weight | 308.31 |
| MDL number | MFCD08277040 |
| PubChem Substance ID【PubChem化学物质编号】 | 329770820 |
| General description【一般描述】 | AR-A014418 may have chronic pain-relieving properties. In mice having neuropathic pain, this molecule has been shown to have antihyperalgesic effects. AR-A014418 may modulate proinflammatory cytokines and the catecholaminergic and serotonergic pathways. It has also been studied that AR-A014418 inhibits growth of pancreatic cancer cells. |
| Application【应用】 | AR-A014418 has been used as an inhibitor of glycogen synthase kinase 3 (GSK3). |
| Biochem/physiol Actions【生化/生理作用】 | Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer′s disease. GSK3 inhibitor, AR-A014418, inhibits GSK3 (IC50 = 104 nM), in an ATP-competitive manner (Ki = 38 nM). AR-A014418 does not significantly inhibit cdk2 or cdk5 (IC50 > 100 μM) or 26 other kinases, demonstrating high specificity for GSK3. |
| Features and Benefits【特点和优势】 | This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | off-white to tan |
| solubility【溶解性】 | DMSO: ≥20 mg/mL, clear, light yellow H2O: insoluble |
| originator【创始人】 | AstraZeneca |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | COc1ccc(CNC(=O)Nc2ncc(s2)[N+]([O-])=O)cc1 |
| InChI | 1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12)16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17) |
| InChI key | YAEMHJKFIIIULI-UHFFFAOYSA-N |
| packaging【包装】 | 5 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
