CGP 57380

C₁₁H₉FN₆

244.23

MFCD03861062

24724432

CGP 57380 has been used:

• as a mitogen-activated protein kinase-interacting kinase 1 (MNK1) inhibitor to investigate the role of Mnk1 on eukaryotic translation initiation factor 4F (eIF4F) assembly and Newcastle disease virus (NDV) replication in HeLa cells
• as an MNK1 inhibitor to block eIF4 complex to evaluate the contribution of interferon (IFN-γ) translation during m157- transgenic (Tg) stimulation
• as a β-catenin nuclear translocation inhibitor to analyze its effects on cytoplasmic and nuclear fractions of cells

CGP 57380 is a β-catenin nuclear translocation inhibitor, which prevents the proliferation of several cancers. It enhances radiation-induced apoptosis in nasopharyngeal carcinoma (NPC). CGP 57380 upregulates β-catenin in the cytoplasm and inhibits epithelial-mesenchymal transition (EMT).
CGP 57380 is a cell-permeable selective inhibitor of mitogen-activated protein kinase-interacting kinase 1 (MNK1).

100

≥98% (HPLC)

powder

white to beige

DMSO: 10 mg/mL, clear
H₂O: <2 mg/mL

2-8℃

Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12

1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18)

UQPMANVRZYYQMD-UHFFFAOYSA-N

5, 25 mg in glass bottle

11 - Combustible Solids

WGK 3

Eyeshields, Gloves, type N95 (US)