Purvalanol A-CAS 212844-53-6-Calbiochem

C₁₉H₂₅ClN₆O

388.89

MFCD02179211

A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC₅₀ = 4 nM for Cdc2-cyclin B; IC₅₀ = 70 nM for Cdk2-cyclin A; IC₅₀ = 35 nM for Cdk2-cyclin E; and IC₅₀ = 75 nM for Cdk5-p35).
A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases (Cdks; IC₅₀ = 4 nM for Cdc2/cyclin B; IC₅₀ = 70 nM for Cdk2/cyclin A; IC₅₀ = 35 nM for Cdk2/cyclin E; and IC₅₀ = 75 nM for Cdk5/p35).

Product does not compete with ATP.
Primary Target
Cdc2/cyclin B
Reversible: yes
Cell permeable: yes
Target IC₅₀: 4 nM for Cdc2/cyclin B; 70 nM for Cdk2/cyclin A; 35 nM for Cdk2/cyclin E; 75 nM for Cdk5/p35

Toxicity: Standard Handling (A)

Following initial thaw, aliquot and freeze (-20°C).

Gray, N.S., et al. 1998. Science 281, 533.

Sold under license of U.S. Patents 6,617,331 and 6,803,371.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

≥97% (HPLC)

solid

Calbiochem^®

OK to freeze

off-white

DMSO: 100 mg/mL

ambient

−20℃

1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1

PMXCMJLOPOFPBT-HNNXBMFYSA-N

1 mg in Plastic ampoule
Packaged under inert gas

11 - Combustible Solids

WGK 3