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Bisindolylmaleimide I-CAS 133052-90-1-Calbiochem
| 产品编号： | 4075611 |
| 规格： | A highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (IC50 = 10 nM) that is structurally similar to staurosporine. |
| CAS NO： | 133052-90-1 |
| 包装规格： | 250 μG，1 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 4075611 | 250 μG | 889 | 2-5天 | 4-6周 | |
| 4075611 | 1 MG | 2570 | 2-5天 | 4-6周 |
产品别名
133052-90-1
Bisindolylmaleimide I-CAS 133052-90-1-Calbiochem
2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-maleimide, Gö 6850, GF 109203X
基本信息
| Empirical Formula【经验(实验)分子式】 | C25H24N4O2 |
| Molecular weight | 412.48 |
| MDL number | MFCD00236428 |
| General description【一般描述】 | A highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (IC50 = 10 nM) that is structurally similar to staurosporine. Acts as a competitive inhibitor for the ATP-binding site of PKC. Shows high selectivity for PKCα-, βI-, βII-, γ-, δ-, and ε- isozymes. Potently inhibits GSK-3 in primary adipocyte lysates (IC50 = 360 nM) and in GSK-3β immunoprecipitates (IC50 = 170 nM). May inhibit protein kinase A at a much higher concentration (IC50 = 2 µM). A 1 mg/ml solution of Bisindolylmaleimide I (Cat. No. 203293) in anhydrous DMSO is also available. A highly selective cell-permeable protein kinase C (PKC) inhibitor (IC50 = 10 nM) that is structurally similar to staurosporine. Acts as a competitive inhibitor for the ATP-binding site of PKC. Shows high selectivity for PKCα, βI, βII, γ, δ, and ε isozymes. May inhibit protein kinase A at a much higher concentration (IC50 = 2 µM). Also inhibits telomerase activity in quercetin, H-89, or herbimycin A treated NPC-076 cells. |
| Biochem/physiol Actions【生化/生理作用】 | Reversible: yes Primary Target PKC Cell permeable: yes Target IC50: 10 nM against protein kinase C (PKC); 360 nM, 170 nM against GSK-3 in primary adipocyte lysates and in GSK-3β immunoprecipitates, respectively Product competes with ATP. |
| Warning【警告】 | Toxicity: Standard Handling (A) |
| Preparation Note【制备说明】 | Further dilute with aqueous buffers just prior to use. |
| Reconstitution【重悬】 | Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 4 months at -20°C. |
| Other Notes【其他说明】 | Hers, I., et al. 1999. FEBS Lett.460, 433. Ku, W.-C., et al. 1997. Biochem. Biophys. Res. Commun. 241, 730. Gekeler, V., et al. 1996. Br. J. Cancer 74, 897. Kiss, Z., et al. 1995. Biochim. Biophys. Acta 1265, 93. Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771. |
| Legal Information【法律信息】 | CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥95% (HPLC) |
| form【形式】 | solid |
| manufacturer/tradename | Calbiochem® |
| storage condition【储存条件】 | OK to freeze protect from light |
| color【颜色】 | deep orange |
| solubility【溶解性】 | DMSO: 10 mg/mL |
| shipped in【运输】 | ambient |
| storage temp.【储存温度】 | 2-8℃ |
| InChI | 1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31) |
| InChI key | QMGUOJYZJKLOLH-UHFFFAOYSA-N |
| packaging【包装】 | 250 μg in Plastic ampoule 1 mg in Plastic ampoule |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
