Antipain, Hydrochloride-CAS 37682-72-7-Calbiochem

C₂₇H₄₄N₁₀O₆ · xHCl

604.70 (free base basis)

MFCD00135957

Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca²⁺-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain and some cysteine proteases (IC₅₀ = 300 µM).
Peptidyl arginine aldehyde protease inhibitor produced by actinomycetes. Inhibitor of Ca²⁺-dependent endopeptidases. Has specificity similar to Leupeptin (Cat. No. 108975). Inhibits trypsin-like serine proteases, papain, and some cysteine proteases (IC₅₀ ~500 ng/ml). Effective at concentrations of 1-100 µM.
Effective concentration: 1-100 µM.

Product does not compete with ATP.
Primary Target
Trypsin-like serine proteases
Reversible: no
Cell permeable: no
Target IC₅₀: 300 µM against trypsin-like serine proteases, papain and some cysteine proteases

Toxicity: Standard Handling (A)

Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.

Lyupina, Y.V., et al. 1996. Eur. J. Pharmacol. 304, 23.
Umezawa, H. 1976. Methods Enzymol.55, 678.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

100

solid

Calbiochem^®

OK to freeze
desiccated (hygroscopic)

white to slightly yellowish

water: 10 mg/mL

ambient

2-8℃

1S/C27H44N10O6.2ClH/c1-16(2)21(34-18(15-38)10-6-12-32-25(28)29)23(40)37-22(39)19(11-7-13-33-26(30)31)35-27(43)36-20(24(41)42)14-17-8-4-3-5-9-17;;/h3-5,8-9,15-16,18-21,34H,6-7,10-14H2,1-2H3,(H,41,42)(H4,28,29,32)(H4,30,31,33)(H2,35,36,43)(H,37,39,40);2*1H/t18?,19-,20?,21-;;/m0../s1

GXQPAKIVOCLCHD-BXLPLHKWSA-N

10 mg in Plastic ampoule
5 mg in Glass bottle

11 - Combustible Solids

WGK 3