Dde-Lys(Fmoc)-OH

C₃₁H₃₆N₂O₆

532.63

Quasi-orthogonally-protected Lys derivative. The Fmoc group can be removed selectively by treatment with piperidine; the Dde group is cleaved with 2% hydrazine in DMF [1]. When removing Dde in the presence of allyl-based protecting groups, allyl alcohol should be included in the deprotection solution to prevent reduction of the allyl group [2].

Also available Fmoc-Lys(Dde)-OH 852057.

This derivative has been employed in Fmoc SPPS to facilitate the introduction of biotin to the side-chain of lysine [3].

The product number for this product was previously 04-12-5201.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

Replaces: 04-12-5201

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(157B)): ≥ 97 %
Purity (TLC(CMA2)): ≥ 97 %
Assay (HPLC, area%): ≥ 96.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 90.0 %
Water (K. F.): ≤ 1.00 %
For TLC-Systems see our General Catalog

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

200

Novabiochem^®

≥90.0% (acidimetric)
≥96.0% (HPLC)
≥97% (TLC)

powder

reaction type: Fmoc solid-phase peptide synthesis

Novabiochem^®

>70 ℃ (decomposition)

Fmoc

15-25℃

11 - Combustible Solids

WGK 2