HBTU

C₁₁H₁₆F₆N₅OP

379.24

MFCD00075445

423-020-5

TBTU and HBTU are two of the most popular in situ activation reagents used in solid phase and solution phase peptide synthesis [1-9]. These reagents offer reactivity similar to symmetrical anhydrides and BOP [1]. Couplings proceed smoothly and rates can even be enhanced by the addition of HOBt [2, 4, 5, 6]. In addition to having high reactivity, TBTU and HBTU have also been shown to limit enantiomerization during fragment condensation and during DMAP catalyzed esterification of arginine derivatives [3]. Comparative experiments between HBTU and TBTU have shown that the counter ion has no influence on coupling rates or levels of enantiomerization [1].

The product number for this product was previously 01-62-0010.

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Replaces: 01-62-0010

Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

300

Novabiochem^®

≥99.0% (HPLC)

powder

>2000 mg/kg LD₅₀, oral (Rat)

reaction type: Coupling Reactions

Novabiochem^®

4.1 (1.6 g/L in H₂O)

250 ℃

1.6 g/L

peptide synthesis

2-8℃

1S/C11H16N5O/c1-14(2)11(15(3)4)17-16-10-8-6-5-7-9(10)12-13-16/h5-8H,1-4H3/q+1

CLZISMQKJZCZDN-UHFFFAOYSA-N

GHS07,GHS08

Danger

H315 - H317 - H319 - H334 - H335

P261 - P264 - P280 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

Respiratory system

11 - Combustible Solids

WGK 3