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Amyloid Precursor Protein α, Secreted human
| 产品编号： | 4096470 |
| 规格： | >90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution |
| 包装规格： | 25 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Amyloid Precursor Protein α, Secreted human
sAPPα
基本信息
| MDL number | MFCD03454663 |
| NACRES | NA.32 |
| General description【一般描述】 | The APP (amyloid precursor protein) gene is mapped to human chromosome 21q21.3. It encodes a integral membrane protein. APPα is a soluble protein generated by sequential cleavage with α and γ secretase. |
| Application【应用】 | Human amyloid precursor protein α secreted, has been used in enzyme linked immunosorbent assay (ELISA). |
| Biochem/physiol Actions【生化/生理作用】 | Amyloid precursor protein α is an α-secretase-cleaved soluble protein that has been shown to have neuroprotective properties. It is derived from amyloid precursor protein. The protein consists of 612 amino acids. Several G protein-coupled receptors are known to activate α-secretase-dependent processing of APP. It has neuroprotective, neurogenic and neurotrophic functions. Amyloid precursor protein a also stimulates gene expression and protein expression. |
| Physical form【外形】 | Solution 0.2 μm filtered, in phosphate buffered saline, pH 7.4. |
| Preparation Note【制备说明】 | Expressed as a soluble protein and purified under non-denaturing conditions. |
产品性质
| Quality Level【质量水平】 | 200 |
| recombinant【重组】 | expressed in E. coli (N-terminal histidine tagged) |
| Assay【测定】 | >90% (SDS-PAGE) |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | ~100 kDa by SDS-PAGE |
| UniProt accession no.【UniProt登记号】 | P05067 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −70℃ |
| Gene Information | human ... APP(351) |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | nwg |
