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Urocortin human
产品别名
176591-49-4
Urocortin human
基本信息
| Empirical Formula【经验(实验)分子式】 | C204H337N63O64 |
| Molecular weight | 4696.24 |
| MDL number | MFCD00802621 |
| NACRES | NA.32 |
| Amino Acid Sequence | Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2 |
| Application【应用】 | Urocortin human can be used as a test compound for studying the impact of corticotropin-releasing factor (CRF) receptor agonist and antagonist on sleep-wake patterns in conscious rats by using radiotelemetry system. |
| Biochem/physiol Actions【生化/生理作用】 | Urocortin is a CRF-related neuropeptide having high affinity for CRF2 receptor possess appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein. Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells. |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | human |
| Assay【测定】 | ≥85% (HPLC) |
| form【形式】 | powder |
| technique(s) | ligand binding assay: suitable |
| UniProt accession no.【UniProt登记号】 | P55089 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... UCN(7349) |
| packaging【包装】 | 250 μg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
